httpd: Syntax error on line 496 of /opt/local/apache2/conf/httpd.conf: Could not open configuration file /opt/local/apache2/conf/extra/mod_php.conf: No such file or directory

% /opt/local/apache2/bin/apachectl -k restart

httpd: Syntax error on line 496 of /opt/local/apache2/conf/httpd.conf: Could not open configuration file /opt/local/apache2/conf/extra/mod_php.conf: No such file or directory

PHPのバージョンをあげた際など、mod_php.confmod_php55.confなどに切り替わっている場合があります。

確認し、該当の名前へ書き換えましょう。